| 2021-01-03 15:00:143rd January 2021 | Caledonia Pride  |  Oaklands Wolves | Preview |
| 2021-01-09 15:00:489th January 2021 | Caledonia Pride |  BA London Lions | Preview |
| 2021-01-16 15:00:1416th January 2021 | Caledonia Pride |  Leicester Riders | Preview |
| 2021-01-23 13:00:5123rd January 2021 | Essex Rebels  | Caledonia Pride | Preview |
| 2021-01-30 15:00:1230th January 2021 | Caledonia Pride |  Sevenoaks Suns | Preview |
| 2021-02-14 17:30:3414th February 2021 | Nottingham Wildcats  | Caledonia Pride | Preview |
| 2021-02-20 15:00:3020th February 2021 | Caledonia Pride |  Newcastle Eagle | Preview |
| 2021-02-28 16:00:3528th February 2021 | Leicester Riders | Caledonia Pride | Preview |
| 2021-03-06 15:15:036th March 2021 | Cardiff Met Archers  | Caledonia Pride | Preview |
| 2021-03-13 15:00:4713th March 2021 | Caledonia Pride | Essex Rebels | Preview |
| 2021-03-14 16:00:0014th March 2021 | Newcastle Eagle | Caledonia Pride | Preview |
| 2021-03-20 15:00:4020th March 2021 | Caledonia Pride | Nottingham Wildcats | Preview |
| 2021-03-28 13:00:0828th March 2021 | BA London Lions | Caledonia Pride | Preview |
| 2021-04-03 15:00:553rd April 2021 | Caledonia Pride |  Manchester Met Mystics | Preview |
| 2021-04-10 15:00:3810th April 2021 | Sevenoaks Suns | Caledonia Pride | Preview |
| 2021-04-17 15:00:3917th April 2021 | Caledonia Pride | Cardiff Met Archers | Preview |
| 2021-04-24 16:00:4824th April 2021 | Manchester Met Mystics | Caledonia Pride | Preview |
| 2021-04-25 16:00:1225th April 2021 | Oaklands Wolves | Caledonia Pride | Preview |
