| 2021-01-16 15:00:1416th January 2021 | Caledonia Pride  |  Leicester Riders | Recap |
| 2021-01-30 15:00:3230th January 2021 | Durham Palatnates  | Caledonia Pride | Recap |
| 2021-02-07 16:00:357th February 2021 | Leicester Riders | Caledonia Pride | Recap |
| 2021-02-14 17:30:3414th February 2021 | Nottingham Wildcats  | Caledonia Pride | Recap |
| 2021-02-17 18:30:3017th February 2021 | Caledonia Pride |  Manchester Met Mystics | Recap |
| 2021-02-20 15:00:3020th February 2021 | Caledonia Pride |  Newcastle Eagle | Recap |
| 2021-02-28 15:00:1428th February 2021 | Caledonia Pride |  Oaklands Wolves | Recap |
| 2021-03-06 15:15:036th March 2021 | Cardiff Met Archers  | Caledonia Pride | Recap |
| 2021-03-13 15:00:4713th March 2021 | Caledonia Pride |  Essex Rebels | Recap |
| 2021-03-14 13:30:0014th March 2021 | Newcastle Eagle | Caledonia Pride | Recap |
| 2021-03-21 15:00:2921st March 2021 | Caledonia Pride | Durham Palatnates | Recap |
| 2021-03-24 18:00:4024th March 2021 | Caledonia Pride | Nottingham Wildcats | Recap |
| 2021-03-28 13:00:0828th March 2021 | BA London Lions  | Caledonia Pride | Recap |
| 2021-04-03 15:00:553rd April 2021 | Caledonia Pride | Manchester Met Mystics | Recap |
| 2021-04-07 18:00:077th April 2021 | Caledonia Pride | BA London Lions | Recap |
| 2021-04-10 13:30:3810th April 2021 | Sevenoaks Suns  | Caledonia Pride | Recap |
| 2021-04-17 12:30:3917th April 2021 | Caledonia Pride | Cardiff Met Archers | Recap |
| 2021-04-24 14:00:4824th April 2021 | Manchester Met Mystics | Caledonia Pride | Recap |
| 2021-04-25 15:00:1225th April 2021 | Oaklands Wolves | Caledonia Pride | Recap |
| 2021-04-28 18:00:2328th April 2021 | Caledonia Pride | Sevenoaks Suns | Recap |
